123-08-0

  • Product Name4-Hydroxybenzaldehyde
  • Molecular FormulaC7H6O2
  • Molecular Weight122.123
  • Purity99%
  • Appearanceyellow to light brown crystalline powder
Inquiry

Product Details

Quick Details

  • CasNo: 123-08-0
  • Molecular Formula: C7H6O2
  • Appearance: yellow to light brown crystalline powder
  • Purity: 99%

Excellent chemical plant bulk supply 4-Hydroxybenzaldehyde 123-08-0

  • Molecular Formula:C7H6O2
  • Molecular Weight:122.123
  • Appearance/Colour:yellow to light brown crystalline powder 
  • Vapor Pressure:0.0171mmHg at 25°C 
  • Melting Point:112-116°C(lit.) 
  • Refractive Index:1.618 
  • Boiling Point:246.6 °C at 760 mmHg 
  • Flash Point:101.3 °C 
  • PSA:37.30000 
  • Density:1.226 g/cm3 
  • LogP:1.20470 

4-Hydroxybenzaldehyde(Cas 123-08-0) Usage

Chemical Description

4-hydroxybenzaldehyde is an organic compound with a hydroxyl group and an aldehyde group.

Chemical Composition and Structure

4-Hydroxybenzaldehyde (4-HBA) is an organic compound belonging to the class of hydroxybenzaldehydes. It is characterized by a benzene ring with a hydroxyl group (-OH) and an aldehyde group (-CHO) attached at the para position.

Sources

4-Hydroxybenzaldehyde is found naturally in plants such as Gastrodia elata (Tianma) and Vanilla planifolia (vanilla orchid). It can also be synthesized chemically.

Mechanism of Action

4-Hydroxybenzaldehyde has been studied for its various biological activities, including its ability to inhibit GABA transaminase, modulate bacterial metabolism, and act as a flavoring agent. Its mechanism of action involves interactions with specific molecular targets, such as enzymes and receptors.

InChI:InChI=1/C7H6O2/c8-5-6-1-3-7(9)4-2-6/h1-5,9H

123-08-0 Relevant articles

-

Brady,Jakobovits

, p. 767,769, 777 (1950)

-

Selective synthesis of p-hydroxybenzaldehyde by liquid-phase catalytic oxidation of p-cresol

Rode, Chandrashekhar V.,Sonar, Mahesh V.,Nadgeri, Jayprakash M.,Chaudhari, Raghunath V.

, p. 873 - 878 (2004)

Liquid-phase oxidation of p-cresol over ...

Practical process for the air oxidation of cresols: Part B. evaluation of the laboratory-scale oxidation process

Barton, Benita,Logie, Catherine G.,Schoonees, Barbara M.,Zeelie, Bernard

, p. 70 - 79 (2005)

Mechanistic proposals and predictions ma...

Synthesis of Copolymers of N-Vinylpyrrolidone with Crotonic Acid Modified with 4-Oxybenzaldehyde

Solovskii,Borisenko,Tarabukina,Amirova

, p. 514 - 519 (2018)

Radical copolymerization of N-vinylpyrro...

A novel practical cleavage of tert-butyl esters and carbonates using fluorinated alcohols

Choy, Jason,Jaime-Figueroa, Saul,Lara-Jaime, Teresa

, p. 2244 - 2246 (2010)

Thermolytic cleavage of t-butyl esters a...

Increased para Selectivity in the Reimer-Tiemann Reaction by Use of Polyethylene Glycol as Complexing Agent

Neumann, Ronny,Sasson, Yoel

, p. 569 - 570 (1986)

The para selectivity of the Reimer-Tiema...

Novel and efficient oxidation of benzyl ethers to benzaldehydes by DMSO/49% aq. HBr

Naik, Ramesh,Pasha

, p. 1723 - 1726 (2007)

Dimethylsulfoxide (DMSO) oxidizes benzyl...

Total synthesis of the proposed structures of gladiosides I and II

Hussain, Nazar,Delar, Emmanilo,Piochon, Marianne,Groleau, Marie-Christine,Tebbji, Faiza,Sellam, Adnane,Déziel, Eric,Gauthier, Charles

, (2021)

Burkholderia gladioli is a Gram-negative...

Aqueous selective photocatalytic oxidation of salicyl alcohol by TiO2 catalysts: Influence of some physico-chemical features

Yurdakal, Sedat,Bellardita, Marianna,Pibiri, Ivana,Palmisano, Leonardo,Loddo, Vittorio

, p. 16 - 24 (2021)

Partial photocatalytic oxidation of sali...

Iron-Catalyzed Synthesis of the Hexahydrocyclopenta[c]furan Core and Concise Total Synthesis of Polyflavanostilbene B

Wang, Xujie,Liu, Fu,Yun, Juping,Feng, Ziming,Jiang, Jianshuang,Yang, Yanan,Zhang, Peicheng

, p. 10127 - 10131 (2018)

The first synthesis of polyflavanostilbe...

Oxidation of p-cresol to p-hydroxybenzaldehyde with molecular oxygen in the presence of CuMn-oxide heterogeneous catalyst

Wang, Feng,Yang, Guanyu,Zhang, Wei,Wu, Wenhai,Xu, Jie

, p. 633 - 638 (2004)

A high-yield synthesis of p-hydroxybenza...

Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging

Fási, Laura,Di Meo, Florent,Kuo, Ching-Ying,Stojkovic Buric, Sonja,Martins, Ana,Kúsz, Norbert,Béni, Zoltán,Dékány, Miklós,Balogh, Gy?rgy Tibor,Pesic, Milica,Wang, Hui-Chun,Trouillas, Patrick,Hunyadi, Attila

, p. 1657 - 1668 (2019)

Cancer cells generally possess higher le...

Highly active nanostructured Co3O4 catalyst with tunable selectivity for liquid phase air oxidation of p-cresol

Kshirsagar, Vikas S.,Vijayanand, Subramanian,Potdar, Hari S.,Joy, Pattayil A.,Patil, Kashinath R.,Rode, Chandrashekhar V.

, p. 310 - 311 (2008)

This is a first report of highly efficie...

Enzymatic oxidative coupling of hydroxyphenylglycine derivatives

Guo, Zhi-Wei,Machiya, Koji,Ma, You-An,Sih, Charles J.

, p. 5679 - 5682 (1998)

In contrast to N-protected tyrosine deri...

Reduced Graphene Oxide Composite with Oxidizable Manganese/Cobalt Mixed Oxide for p-Cresol Oxidation by Using Molecular Oxygen

Jha, Ajay,Patil, Sagar H.,Solanki, Bhanu P.,Ribeiro, Ana P. C.,Castro, Carlos A. N.,Patil, Kashinath R.,Coronas, Alberto,Rode, Chandrashekhar V.

, p. 1164 - 1169 (2015)

A composite of graphene oxide (GO) with ...

Specific Catalysis by α-Cyclodextrin on the Dichlorocarbene Attack at Phenolate

Komiyama, Makoto,Hirai, Hidefumi

, p. 2053 - 2056 (1981)

A selsctive attack of dichlorocarbene at...

-

Amakasu,T.,Sato,K.

, p. 1428 - 1432 (1967)

-

FORMATION OF p-HYDROXYBENZOIC ACID FROM p-COUMARIC ACID BY CELL FREE EXTRACT OF LITHOSPERMUM ERYTHRORHIZON CELL CULTURES

Yazaki, Kazufumi,Heide, Lutz,Tabata, Mamoru

, p. 2233 - 2236 (1991)

The enzymatic formation of p-hydroxybenz...

Novel synthesis of Ag decorated TiO2 anchored on zeolites derived from coal fly ash for the photodegradation of bisphenol-A

Hlekelele, Lerato,Franklyn, Paul J.,Dziike, Farai,Durbach, Shane H.

, p. 1902 - 1912 (2018)

The disposal of millions of tons of coal...

Halicloic acids A and B isolated from the marine sponge Haliclona sp. collected in the Philippines inhibit indoleamine 2,3-dioxygenase

Williams, David E.,Steino, Anne,De Voogd, Nicole J.,Mauk, A. Grant,Andersen, Raymond J.

, p. 1451 - 1458 (2012)

Two new merohexaprenoids, halicloic acid...

-

Kratzl,Billek

, p. 845,854 (1954)

-

Selective oxidation of aromatic hydrocarbons by potassium and phosphorous-modified iron oxide-silica nanocomposite

Masoudian, Shahla,Monfared, Hassan Hosseini

, p. 37 - 43 (2012)

Supported iron catalysts are active for ...

Photochromism of the synthetic 4′,7-dihydroxyflavylium chloride

Figueiredo, Paulo,Lima, Jo?o C.,Santos, Helena,Wigand, Marie-Claude,Brouillard, Raymond,Ma?anita, António L.,Pina, Fernando

, p. 1249 - 1254 (1994)

The synthetic compound 4′,7-dihydroxyfla...

Metal incorporated Horseradish Peroxidase (HRP) catalyzed oxidation of resveratrol: Selective dimerization or decomposition

Li, Chang,Xu, Xiaofei,Lu, Jing,Wang, Lin,Pan, Yuanjiang

, p. 22976 - 22980 (2013)

Horseradish Peroxidase (HRP) is a commer...

-

Hodgson,Jenkinson

, p. 469,470 (1929)

-

BIOSYNTHESIS OF TUBERIN AND XANTHOCILLIN FROM TYROSINE

Herbert, Richard B.,Mann, Jonathan

, p. 4263 - 4266 (1984)

(2S)-Tyrosine (5) is incorporated stereo...

A highly stable zeotype mesoporous zirconium metal-organic framework with ultralarge pores

Feng, Dawei,Wang, Kecheng,Liu, Tian-Fu,Park, Jihye,Wei, Zhangwen,Bosch, Mathieu,Zhou, Hong-Cai,Su, Jie,Zou, Xiaodong,Yakovenko, Andrey

, p. 149 - 154 (2015)

Through topological rationalization, a z...

Copper and manganese: Two concordant partners in the catalytic oxidation of p-cresol to p-hydroxybenzaldehyde

Wang, Feng,Yang, Guan-Yu,Zhang, Wei,Wu, Wen-Hai,Xu, Jie

, p. 1172 - 1173 (2003)

Copper and manganese were found to be tw...

PHOTOCATALYTIC OXIDATION OF p-CRESOL IN AQUEOUS TITANUM DIOXIDE SUSPENSION

Brezova, Vlasta,Brandsteterova, Eva,Ceppan, Michal,Pies, Juraj

, p. 1285 - 1293 (1993)

The reaction products of the photocataly...

-

Tsuji,Ohno

, p. 3969 (1965)

-

Mechanism of the redox reaction of the aequorea green fluorescent protein (GFP)

Kojima, Satoshi,Hirano, Takashi,Niwa, Haruki,Ohashi, Mamoru,Inouye, Satoshi,Tsuji, Frederick I.

, p. 2875 - 2878 (1997)

A model compound, 4-(4-hydroxypheny])met...

Synthesis and antioxidant properties of a new lipophilic ascorbic acid analogue

Cotelle, Philippe,Cotelle, Nicole,Teissier, Elisabeth,Vezin, Herve

, p. 1087 - 1093 (2003)

4-(4-Hydroxyphenyl)-5-(4-hydroxyphenylme...

-

Omura,Matsuura

, p. 1516 (1969)

-

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

Umuhire Juru, Aline,Cai, Zhengguo,Jan, Adina,Hargrove, Amanda E.

, p. 3555 - 3558 (2020)

This study establishes the applicability...

Acid-promoted reaction of the stilbene antioxidant resveratrol with nitrite ions: Mild phenolic oxidation at the 4′-hydroxystiryl sector triggering nitration, dimerization, and aldehyde-forming routes

Panzella, Lucia,De Lucia, Maria,Amalfitano, Carmine,Pezzella, Alessandro,Evidente, Antonio,Napolitano, Alessandra,D'Ischia, Marco

, p. 4246 - 4254 (2006)

In 0.1 M phosphate buffer, pH 3.0, and a...

The Enzyme-catalysed Electrochemical Conversion of p-Cresol into p-Hydroxybenzaldehyde

Hill, H. Allen O.,Oliver, B. Nigel,Page, David J.,Hopper, David J.

, p. 1469 - 1471 (1985)

The electrochemical oxidation of p-creso...

Absolute structures of C-glucosides of resveratrol oligomers from Shorea uliginosa

Ito, Tetsuro,Abe, Naohito,Oyama, Masayoshi,Iinuma, Munekazu

, p. 2516 - 2520 (2009)

Two C-glucosides of resveratrol dimers (...

Assignment of resonance Raman spectrum of photoactive yellow protein in its long-lived blue-shifted intermediate

Unno, Masashi,Kumauchi, Masato,Sasaki, Jun,Tokunaga, Fumio,Yamauchi, Seigo

, p. 2837 - 2845 (2003)

Photoactive yellow protein (PYP) is a ba...

A highly photosensitive covalent organic framework with pyrene skeleton as metal-free catalyst for arylboronic acid hydroxylation

Chen, Ying,Huo, Jianqiang,Zhang, Yubao

, (2022/03/16)

Covalent organic frameworks (COFs) have ...

Biocatalytic Cross-Coupling of Aryl Halides with a Genetically Engineered Photosensitizer Artificial Dehalogenase

Fu, Yu,Huang, Jian,Wu, Yuzhou,Liu, Xiaohong,Zhong, Fangrui,Wang, Jiangyun

supporting information, p. 617 - 622 (2021/02/03)

Devising artificial photoenzymes for abi...

Photocatalytic Reductive C-O Bond Cleavage of Alkyl Aryl Ethers by Using Carbazole Catalysts with Cesium Carbonate

Yabuta, Tatsushi,Hayashi, Masahiko,Matsubara, Ryosuke

, p. 2545 - 2555 (2021/02/01)

Methods to activate the relatively stabl...

SBA-15 Supported Silver Catalyst for the Efficient Aerobic Oxidation of Toluene Under Solvent-Free Conditions

Chen, Lei,Chen, Yanjiao,Dai, Xuan,Guo, Jiaming,Peng, Xinhua

, (2021/12/09)

The efficient SBA-15 supported silver ca...

123-08-0 Process route

4-(1,3-dithiolan-2-yl)phenol
22068-49-1

4-(1,3-dithiolan-2-yl)phenol

4-nitro-phenol
100-02-7,78813-13-5,89830-32-0

4-nitro-phenol

4-hydroxy-3-nitrobenzaldehyde
3011-34-5

4-hydroxy-3-nitrobenzaldehyde

4-hydroxy-benzaldehyde
123-08-0,65581-83-1

4-hydroxy-benzaldehyde

4-[1,3]dithiolan-2-yl-2-nitro-phenol

4-[1,3]dithiolan-2-yl-2-nitro-phenol

Conditions
Conditions Yield
With bismuth(III) nitrate; water; In benzene; at 20 ℃; for 8h; Product distribution;
methyl p-hydroxycinnamate
3943-97-3,19367-38-5,61240-27-5

methyl p-hydroxycinnamate

4-nitro-phenol
100-02-7,78813-13-5,89830-32-0

4-nitro-phenol

3‐nitro‐p‐coumaric acid methyl ester
90729-87-6

3‐nitro‐p‐coumaric acid methyl ester

C<sub>10</sub>H<sub>11</sub>ClO<sub>4</sub>

C10H11ClO4

4-hydroxy-benzaldehyde
123-08-0,65581-83-1

4-hydroxy-benzaldehyde

Conditions
Conditions Yield
With hydrogenchloride; water; dihydrogen peroxide; sodium hydroxide; sodium nitrite; In aq. buffer;

123-08-0 Upstream products

  • 50-00-0
    50-00-0

    formaldehyd

  • 139-02-6
    139-02-6

    sodium phenoxide

  • 64-18-6
    64-18-6

    formic acid

  • 27914-73-4
    27914-73-4

    4-acetoxybenzoyl chloride

123-08-0 Downstream products

  • 27559-50-8
    27559-50-8

    (E)-3-(4-hydroxyphenyl)-N-phenylacrylamide

  • 500859-97-2
    500859-97-2

    4-hydroxy-3-(piperidin-1-ylmethyl)benzaldehyde

  • 486-30-6
    486-30-6

    2-(4-hydroxyphenyl)-2-(piperidin-1-yl)acetonitrile

  • 3421-18-9
    3421-18-9

    2,5-dimorpholinocyclohexa-2,5-diene-1,4-dione

Relevant Products

*Product Name
CasNo
Quantity
Company Name
Phone
*Email
*Description
*Code
Items marked with * are mandatory
Submit