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Product Details
Side effects |
An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects. |
Safety Profile |
Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx. |
Enzyme inhibitor |
This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor. |
Brand name |
Nulsa (Wallace). |
InChI:InChI=1/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
Phosphine-mediated deoxygenative nucleop...
Aryne chemistry has recently received wi...
New derivatives of aspartic and glutamic...
benzyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate
proglumide
Conditions | Yield |
---|---|
With
palladium on activated charcoal; hydrogen;
In
methanol;
at 20 ℃;
for 1h;
|
95% |
N-benzoyl-DL-glutamic acid-anhydride
di-n-propylamine
proglumide
proglumide
Conditions | Yield |
---|---|
In
tetrahydrofuran;
at 25 ℃;
for 3h;
|
16.2% |
N-benzoyl-DL-glutamic acid-anhydride
di-n-propylamine
N-benzoyl-L-glutamic acid γ-methyl ester
L-glutamic acid 5-methyl ester
5-dipropylamino-4(S)-benzamido-5-oxo-pentanoic acid
5-dipropylamino-4(R)-benzamido-5-oxo-pentanoic acid
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