6620-60-6

  • Product NameProglumide
  • Molecular FormulaC18H26N2O4
  • Molecular Weight334.415
  • Purity99%
  • AppearanceWhite solid
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Product Details

Quick Details

  • CasNo: 6620-60-6
  • Molecular Formula: C18H26N2O4
  • Appearance: White solid
  • Purity: 99%

High Quality Chinese Manufacturer supply 6620-60-6 Proglumide

  • Molecular Formula:C18H26N2O4
  • Molecular Weight:334.415
  • Appearance/Colour:White solid 
  • Vapor Pressure:9.33E-15mmHg at 25°C 
  • Melting Point:148-150°C 
  • Refractive Index:1.534 
  • Boiling Point:589.8 °C at 760 mmHg 
  • PKA:4.51±0.10(Predicted) 
  • Flash Point:310.5 °C 
  • PSA:86.71000 
  • Density:1.136 g/cm3 
  • LogP:2.68930 

Proglumide(Cas 6620-60-6) Usage

Side effects

An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.

Safety Profile

Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor.

Brand name

Nulsa (Wallace).

InChI:InChI=1/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)

6620-60-6 Relevant articles

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Chen, Xiangyang,Houk, Kendall N.,Mo, Jia-Nan,Su, Junqi,Umanzor, Alexander,Zhang, Zheng,Zhao, Jiannan

supporting information, (2022/01/06)

Phosphine-mediated deoxygenative nucleop...

An aryne-based three-component access to α-aroylamino amides

Serafini, Marta,Griglio, Alessia,Viarengo, Sara,Aprile, Silvio,Pirali, Tracey

, p. 6604 - 6612 (2017/08/16)

Aryne chemistry has recently received wi...

New glutamic and aspartic derivatives with potent CCK-antagonistic activity

Makovec,Chiste,Bani,et al.

, p. 9 - 20 (2007/10/02)

New derivatives of aspartic and glutamic...

6620-60-6 Process route

benzyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate

benzyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate

proglumide
6620-60-6,24485-90-3

proglumide

Conditions
Conditions Yield
With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h;
95%
<i>N</i>-benzoyl-<i>DL</i>-glutamic acid-anhydride
91569-94-7

N-benzoyl-DL-glutamic acid-anhydride

di-n-propylamine
142-84-7

di-n-propylamine

proglumide
6620-60-6,24485-90-3

proglumide

proglumide
102743-01-1

proglumide

Conditions
Conditions Yield
In tetrahydrofuran; at 25 ℃; for 3h;
16.2%

6620-60-6 Upstream products

  • 91569-94-7
    91569-94-7

    N-benzoyl-DL-glutamic acid-anhydride

  • 142-84-7
    142-84-7

    di-n-propylamine

  • 14307-84-7
    14307-84-7

    N-benzoyl-L-glutamic acid γ-methyl ester

  • 1499-55-4
    1499-55-4

    L-glutamic acid 5-methyl ester

6620-60-6 Downstream products

  • 32999-84-1
    32999-84-1

    5-dipropylamino-4(S)-benzamido-5-oxo-pentanoic acid

  • 32999-90-9
    32999-90-9

    5-dipropylamino-4(R)-benzamido-5-oxo-pentanoic acid

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