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77-93-0

  • Product NameTriethyl citrate
  • Molecular FormulaC12H20O7
  • Molecular Weight276.287
  • Purity99%
  • Appearanceclear liquid
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Product Details

Quick Details

  • CasNo: 77-93-0
  • Molecular Formula: C12H20O7
  • Appearance: clear liquid
  • Purity: 99%

Top Quality Chinese Factory supply 77-93-0 Triethyl citrate

  • Molecular Formula:C12H20O7
  • Molecular Weight:276.287
  • Appearance/Colour:clear liquid 
  • Vapor Pressure:1 mm Hg ( 107 °C) 
  • Melting Point:-46 °C 
  • Refractive Index:n20/D 1.442(lit.)  
  • Boiling Point:294 °C at 760 mmHg 
  • PKA:11.57±0.29(Predicted) 
  • Flash Point:95.4 °C 
  • PSA:99.13000 
  • Density:1.177 g/cm3 
  • LogP:0.18700 

Triethyl citrate(Cas 77-93-0) Usage

Production Methods

Triethyl citrate is prepared by the esterification of citric acid and ethanol in the presence of a catalyst.

Preparation

By esterification of ethyl alcohol with citric acid.

General Description

Triethyl citrate is a safe direct food additive.

Pharmaceutical Applications

Triethyl citrate and the related esters acetyltriethyl citrate, tributyl citrate, and acetyltributyl citrate are used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations. Triethyl citrate is also used as a direct food additive for flavoring, for solvency, and as a surface active agent.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion and inhalation. Combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS and CITRIC ACID.

Safety

Triethyl citrate is used in oral pharmaceutical formulations and as a direct food additive. It is generally regarded as a nontoxic and nonirritant material. However, ingestion of large quantities may be harmful. LD50 (mouse, IP): 1.75 g/kg LD50 (rat, IP): 4 g/kg LD50 (rat, oral): 5.9 g/kg LD50 (rat, SC): 6.6 g/kg

storage

Triethyl citrate should be stored in a closed container in a cool, dry location. When stored in accordance with these conditions, triethyl citrate is a stable product.

Incompatibilities

Triethyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

InChI:InChI=1/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3

77-93-0 Relevant articles

Citrate plasticizer

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Paragraph 0066-0068, (2021/05/15)

The invention discloses a citrate plasti...

The preparation method of the triethyl citrate

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Paragraph 0037-0050, (2019/07/04)

The invention relates to a method for pr...

METHOD FOR THE PRODUCTION OF METHYLSUCCINIC ACID AND THE ANHYDRIDE THEREOF FROM CITRIC ACID

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Page/Page column 16, (2018/04/21)

A process for the preparation of methyls...

Synthetic method for auxiliary for 3D printing flexible material

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Paragraph 0022; 0023, (2017/02/17)

The invention designs a synthetic method...

77-93-0 Process route

ethanol
64-17-5

ethanol

citric acid
77-92-9,906507-37-7

citric acid

citric acid triethyl ester
77-93-0

citric acid triethyl ester

Conditions
Conditions Yield
ethanol; With dicyclohexyl-carbodiimide; at 20 ℃; for 36h; Large scale;
citric acid; at 35 ℃; for 6h; Temperature; Autoclave; Large scale;
96%
With sulfonated graphene; In neat (no solvent); at 90 ℃; for 4h;
94%
With boric acid; benzenesulfonic acid; at 85 - 90 ℃; for 3h;
93.26%
With sodium hydrogensulfate monohydrate; at 80 - 90 ℃; Reagent/catalyst; Temperature;
90.2%
With toluene-4-sulfonic acid; In toluene; at 90 - 110 ℃; for 4h;
86.3%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 75 ℃; for 3h;
85%
With carbonic acid dimethyl ester; at 180 ℃; for 5h; under 10343.2 Torr; Reagent/catalyst; Temperature; Inert atmosphere;
55.8%
With hydrogenchloride;
 
With hydrogenchloride; in mehreren Stufen;
 
With sulfuric acid; 1,2-dichloro-ethane;
 
With folate;
 
With sulfuric acid; toluene;
 
With sulfuric acid; at 0 - 80 ℃; for 4h;
 
With toluene-4-sulfonic acid; at 60 - 135 ℃; Concentration; Temperature; Further stages; Autoclave;
 
With nanometer intercalation hydrotalcite catalyst with [PW11CoO39]5- polyacid; at 100 - 105 ℃; Reagent/catalyst; Temperature;
 
With benzene; azeotrope Destillation;
 
With toluene-4-sulfonic acid; In cyclohexane; water; at 110 ℃; for 4h;
 
ethanol
64-17-5

ethanol

citric acid
77-92-9,906507-37-7

citric acid

Diethyl 2-methylsuccinate
4676-51-1

Diethyl 2-methylsuccinate

citric acid triethyl ester
77-93-0

citric acid triethyl ester

Conditions
Conditions Yield
With hydrogen; In water; at 200 ℃; for 6h; under 3000.3 Torr;
19 %Spectr.

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