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This drug is obtained from species of the actinomycete Streptomyces and is an aminoglycoside antibiotic (as are streptomycin, gentamicin, and kanamycin) effective against most aerobic gram-negative organisms. Group A streptococci are relatively resistant. Neomycin acts to inhibit bacterial protein synthesis by irreversibly binding to the 30S subunit. It is responsible for a greater incidence of allergic contact sensitivity than any other topical antibiotic. This diagnosis often remains hidden, because morphologically the eruption is of a mild eczematous nature. Rarely, anaphylaxis may occur.
Neomycin sulfate is an antibiotic (can be used effectively against most bacteria that cause skin, eye and outer ear infections); broad-spectrum antibiotic in topical creams, powders, ointments, eye and ear drops; systemic antibiotic and growth promotor in veterinary use.
The CAS number of Neomycin sulfate is 1405-10-3.
More information of Neomycin sulfate 1405-10-3 are:
CAS Number |
1405-10-3 |
Melting Point |
>187°C (dec.) |
Boiling Point |
1046.1oC at 760 mmHg |
Flash Point |
586.5oC |
Vapor Pressure |
0mmHg at 25°C |
Refractive Index |
56 ° (C=10, H2O) |
HS CODE |
29419000 |
PSA |
436.09000 |
LogP |
-4.26550 |
Synonyms for Neomycin sulfate 1405-10-3:Fradiomycinum;Neomycin B AND D-Streptamine, O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy;Nivemycin;Bykomycin;Sofratulle;Prestwick_510;EPA Pesticide Chemical Code 006303;Neomicina [DCIT];Mycifradin;Neomycin sulfate (USP);5-amino-2-(aminomethyl)-6-[(2R,3S,5S)-5-[3,5-diamino-2-[3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-6-hydroxy-cyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy-oxane-3,4-diol; sulfuric acid;Fradiomycin sulfate (JP14);Neomcin;Mycifradin (TN);Fradiomycin sulfate;
The chemical formula of Neomycin sulfate is C23H46N6O13.3(H2SO4) which containing 23 Carbon atoms,48 Hydrogen atoms,6 Nitrogen atoms,2 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of Neomycin sulfate is 908.88.
Neomycin sulfate is an aminoglycoside antibiotic derived from the bacterium Streptomyces fradiae. It is known for its potent antibacterial properties against both Gram-positive and Gram-negative bacteria, making it a versatile and effective agent in various applications. Neomycin sulfate is characterized by its white or yellowish-white powdery appearance and hygroscopic nature.
InChI:InChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6-,7+,8-,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23-;/m1./s1
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