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136-77-6

  • Product Name4-Hexylresorcinol
  • Molecular FormulaC12H18O2
  • Molecular Weight194.274
  • Purity99%
  • Appearanceslightly red powder
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Product Details

Quick Details

  • CasNo: 136-77-6
  • Molecular Formula: C12H18O2
  • Appearance: slightly red powder
  • Purity: 99%

Top Quality Chinese Factory supply 136-77-6 4-Hexylresorcinol

  • Molecular Formula:C12H18O2
  • Molecular Weight:194.274
  • Appearance/Colour:slightly red powder 
  • Vapor Pressure:0.000103mmHg at 25°C 
  • Melting Point:65-67 °C(lit.) 
  • Refractive Index:1.54 
  • Boiling Point:329.5 °C at 760 mmHg 
  • PKA:pKa 9.1 (Uncertain) 
  • Flash Point:155.2 °C 
  • PSA:40.46000 
  • Density:1.049 g/cm3 
  • LogP:3.22060 

4-Hexyl-1,3-benzenediol(Cas 136-77-6) Usage

General Description

Pale-yellow viscous liquid (that becomes solid on standing at room temperature) or a peach colored powder. Pungent faintly fatty odor. Sharp astringent taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Hexyl-1,3-benzenediol may be sensitive to prolonged exposure to light. Incompatible with acid chlorides, acid anhydrides and oxidizing agents .

Hazard

Irritant to respiratory tract and skin, concentrated solutions are vesicant.

Fire Hazard

Flash point data for 4-Hexyl-1,3-benzenediol are not available. 4-Hexyl-1,3-benzenediol is probably combustible.

Biological Activity

hexylresorcinol is a mushroom tyrosinase inhibitor.tyrosinase, a copper-containing enzyme, is distributed in microorganisms, animals, and plants widely. mushroom tyrosinase has been becoming popular due to its availability and usages in various applications.

in vitro

previous results showed hexylresorcinol could inhibit both mono- and di-phenolase activity of mushroom tyrosinase. moreover, hexylresorcinol at 2 μm lengthened the lag period from 98 s to 26. hexylresorcinol could also display reversible inhibition of the enzyme. in addition, the kinetic analyses showed that hexylresorcinol was a competitive inhibitor with the apparent inhibition constant binding with free enzyme to be 0.443 μm for diphenolase [1].

in vivo

previous in vivo study showed that hexylresorcinol could induce chromosome aberrations in mouse eukaryotic cells at doses of 0.5, 0.05, and 0.005 mg/g and the metabolic transformation of hexylresorcinol decreased its genotoxic effect in mice. moreover, the mutagenic effect lasted for 3 days only at the highest dose of hexylresorcinol (0.5 mg/g). thus, hexylresorcinol doses less than 0.5 mg/g were metabolized within two days to the extent of the cytotoxic effect. in addition, hexylresorcinol was transformed at a rate of 0.0025–0.025 mg/day after a single administration to mice [2].

IC 50

1.24 μm

references

[1] chen qx,ke ln,song kk,huang h,liu xd. inhibitory effects of hexylresorcinol and dodecylresorcinol on mushroom (agaricus bisporus) tyrosinase. protein j.2004 feb;23(2):135-41.[2] margulis ab,ozhiganova iv,bushmanova ov,kolpakov ai,il'inskaia on. hexylresorcinol induces chromosome aberrations in mouse peripheral blood cells. genetika. 2005 aug;41(8):1045-8.

InChI:InChI=1/C12H18O2/c1-2-3-4-5-6-10-7-11(13)9-12(14)8-10/h7-9,13-14H,2-6H2,1H3

136-77-6 Relevant articles

Nematic phase formed by V-shaped molecules

Szydlowska, Jadwiga,Matraszek, Joanna,Mieczkowski, Jozef,Gorecka, Ewa,Pociecha, Damian

, p. 107 - 115 (2001)

In the paper there are presented synthes...

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Hurd,McNamee

, p. 104 (1937)

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Preparation method of 4-alkylresorcinol

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Paragraph 0053-0055; 0059-0060, (2021/11/03)

The invention discloses a preparation me...

Preparation method of 4-alkylresorcinol

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Paragraph 0032; 0033; 0034; 0038, (2018/05/01)

The invention discloses a preparation me...

Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists

Liu, Peng,Xu, Xing,Chen, Lili,Ma, Lei,Shen, Xu,Hu, Lihong

, p. 1596 - 1607 (2014/03/21)

Compound 1 (IC50 = 35.2 ± 7.2 μM), a mod...

SKIN LIGHTENING COMPOSITIONS AND METHODS

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Page/Page column 19-21, (2009/01/24)

Skin lightening/even toning compositions...

136-77-6 Process route

C<sub>12</sub>H<sub>14</sub>O<sub>3</sub>

C12H14O3

4-Hexylresorcinol
136-77-6

4-Hexylresorcinol

Conditions
Conditions Yield
With hydrogenchloride; platinum on carbon; hydrogen; In methanol; water; at 70 ℃; under 13501.4 Torr;
94%
4-hexanoylresorcinol
3144-54-5

4-hexanoylresorcinol

4-Hexylresorcinol
136-77-6

4-Hexylresorcinol

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In methanol; at 80 ℃; under 11251.1 Torr; Reagent/catalyst; Autoclave;
86.2%
With hydrogenchloride; amalgamated zinc; In ethanol;
67%
With hydrogenchloride; amalgamated zinc; In ethanol; water; Heating;
With hydrogen; nickel; In methanol; at 70 - 95 ℃; under 7500.75 - 37503.8 Torr; Product distribution / selectivity;
With hydrogenchloride; zinc; In ethanol;
With hydrogenchloride; zinc; In ethanol; water; Heating / reflux;

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