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Product Details
General Description |
Pale-yellow viscous liquid (that becomes solid on standing at room temperature) or a peach colored powder. Pungent faintly fatty odor. Sharp astringent taste. |
Air & Water Reactions |
Insoluble in water. |
Reactivity Profile |
4-Hexyl-1,3-benzenediol may be sensitive to prolonged exposure to light. Incompatible with acid chlorides, acid anhydrides and oxidizing agents . |
Hazard |
Irritant to respiratory tract and skin, concentrated solutions are vesicant. |
Fire Hazard |
Flash point data for 4-Hexyl-1,3-benzenediol are not available. 4-Hexyl-1,3-benzenediol is probably combustible. |
Biological Activity |
hexylresorcinol is a mushroom tyrosinase inhibitor.tyrosinase, a copper-containing enzyme, is distributed in microorganisms, animals, and plants widely. mushroom tyrosinase has been becoming popular due to its availability and usages in various applications. |
in vitro |
previous results showed hexylresorcinol could inhibit both mono- and di-phenolase activity of mushroom tyrosinase. moreover, hexylresorcinol at 2 μm lengthened the lag period from 98 s to 26. hexylresorcinol could also display reversible inhibition of the enzyme. in addition, the kinetic analyses showed that hexylresorcinol was a competitive inhibitor with the apparent inhibition constant binding with free enzyme to be 0.443 μm for diphenolase [1]. |
in vivo |
previous in vivo study showed that hexylresorcinol could induce chromosome aberrations in mouse eukaryotic cells at doses of 0.5, 0.05, and 0.005 mg/g and the metabolic transformation of hexylresorcinol decreased its genotoxic effect in mice. moreover, the mutagenic effect lasted for 3 days only at the highest dose of hexylresorcinol (0.5 mg/g). thus, hexylresorcinol doses less than 0.5 mg/g were metabolized within two days to the extent of the cytotoxic effect. in addition, hexylresorcinol was transformed at a rate of 0.0025–0.025 mg/day after a single administration to mice [2]. |
IC 50 |
1.24 μm |
references |
[1] chen qx,ke ln,song kk,huang h,liu xd. inhibitory effects of hexylresorcinol and dodecylresorcinol on mushroom (agaricus bisporus) tyrosinase. protein j.2004 feb;23(2):135-41.[2] margulis ab,ozhiganova iv,bushmanova ov,kolpakov ai,il'inskaia on. hexylresorcinol induces chromosome aberrations in mouse peripheral blood cells. genetika. 2005 aug;41(8):1045-8. |
InChI:InChI=1/C12H18O2/c1-2-3-4-5-6-10-7-11(13)9-12(14)8-10/h7-9,13-14H,2-6H2,1H3
In the paper there are presented synthes...
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The invention discloses a preparation me...
The invention discloses a preparation me...
Compound 1 (IC50 = 35.2 ± 7.2 μM), a mod...
Skin lightening/even toning compositions...
C12H14O3
4-Hexylresorcinol
Conditions | Yield |
---|---|
With
hydrogenchloride; platinum on carbon; hydrogen;
In
methanol; water;
at 70 ℃;
under 13501.4 Torr;
|
94% |
4-hexanoylresorcinol
4-Hexylresorcinol
Conditions | Yield |
---|---|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 80 ℃;
under 11251.1 Torr;
Reagent/catalyst;
Autoclave;
|
86.2% |
With
hydrogenchloride; amalgamated zinc;
In
ethanol;
|
67% |
With
hydrogenchloride; amalgamated zinc;
In
ethanol; water;
Heating;
|
|
With
hydrogen;
nickel;
In
methanol;
at 70 - 95 ℃;
under 7500.75 - 37503.8 Torr;
Product distribution / selectivity;
|
|
With
hydrogenchloride; zinc;
In
ethanol;
|
|
With
hydrogenchloride; zinc;
In
ethanol; water;
Heating / reflux;
|
4-hexanoylresorcinol
Hexanoyl chloride
recorcinol
1-bromo-2-hexene
2',7'-dihexyl-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one
2,4-bis-(2-diethylamino-ethoxy)-1-hexyl-benzene
4-hexyl-cyclohexane-1,3-dione
5-amino-2-hexylphenol
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