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Product Details
History |
Cytosine is first isolated by hydrolysis of calf thymus tissue by Albrecht Kossel (1853–1927) and A. Neumann during 1893–1894. Thymine’s structure was published in 1900 and confi rmed over the next several years when it was synthesized by several investigators. In 1903, cytosine was synthesized by Henry Lord Wheeler (1867–1914) and Treat B. Johnson, confirming its structure. Uracil was first isolated in 1900 from yeast nucleic acid found in bovine thymus and herring sperm.the methylation of uracil produces thymine; thymine is also called 5-methyluracil because methylation takes place at the fi fth carbon in uracil to produce thymine. |
Biochem/physiol Actions |
Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). |
Purification Methods |
Cytosine crystallises from H2O as the monohydrate which loses water on heating above 100o. Its solubility in H2O is 0.77%. UV: max 267nm ( 6,100) in H2O pH 8.8 and 275nm ( 10,400) in 0.1N HCl. [Hilbert & Johnson J Am Chem Soc 52 1152 1930, Hilbert et al. J Am Chem Soc 57 552 1935, Beistein 25 III/IV 3654.] |
Definition |
ChEBI: An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4. |
General Description |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
InChI:InChI=1/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
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N4-benzoyl-2',3'-didehydro-2',3'-dideoxycytidine
4-N-benzoylcytosine
Cytosine
Conditions | Yield |
---|---|
In
water;
at 40 ℃;
Rate constant;
degradation in various buffers (acidic condition, < pH 6);
|
formamide
pyrimidine-4(3H)-one
2,4-diaminopyrimidine
parabanic acid
isocytosine
Cytosine
oxalic acid
guanidine nitrate
2-oxo-propionic acid
uracil
2,6-diaminopyrimidin-4-ol
adenine
urea
glycine
Conditions | Yield |
---|---|
With
copper(II) choride dihydrate;
In
water;
at 80 ℃;
for 24h;
pH=7.57;
|
1.6 mg 1.7 mg 0.0018 mg 0.1 mg 0.76 mg 0.59 mg 5.6 mg 0.3 mg 0.3 mg 0.13 mg 5 mg 3.8 mg 0.01 mg |
2-chloropyrimidin-4-amine
4-amino-2-methoxypyrimidine
4-ethoxypyrimidin-2-one
2-ethylsulfanyl-pyrimidin-4-ylamine
4-(Methylamino)-2(1H)-pyrimidinone
4-N-Acetylcytosine
3,4,5-trimethoxy-benzoic acid-(2-oxo-1,2-dihydro-pyrimidin-4-ylamide)
4-N-benzoylcytosine
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