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71-30-7

  • Product NameCytosine
  • Molecular FormulaC4H5N3O
  • Molecular Weight111.103
  • Purity99%
  • Appearancewhite solid
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Product Details

Quick Details

  • CasNo: 71-30-7
  • Molecular Formula: C4H5N3O
  • Appearance: white solid
  • Purity: 99%

Factory Export Top Purity Cytosine 71-30-7 In Stock

  • Molecular Formula:C4H5N3O
  • Molecular Weight:111.103
  • Appearance/Colour:white solid 
  • Vapor Pressure:1.46E-08mmHg at 25°C 
  • Melting Point:>300 °C(lit.) 
  • Refractive Index:1.688 
  • Boiling Point:445.8 °C at 760 mmHg 
  • PKA:4.60, 12.16(at 25℃) 
  • Flash Point:223.4 °C 
  • PSA:71.77000 
  • Density:1.55 g/cm3 
  • LogP:-0.06670 

Cytosine(Cas 71-30-7) Usage

History

Cytosine is first isolated by hydrolysis of calf thymus tissue by Albrecht Kossel (1853–1927) and A. Neumann during 1893–1894. Thymine’s structure was published in 1900 and confi rmed over the next several years when it was synthesized by several investigators. In 1903, cytosine was synthesized by Henry Lord Wheeler (1867–1914) and Treat B. Johnson, confirming its structure. Uracil was first isolated in 1900 from yeast nucleic acid found in bovine thymus and herring sperm.the methylation of uracil produces thymine; thymine is also called 5-methyluracil because methylation takes place at the fi fth carbon in uracil to produce thymine.

Biochem/physiol Actions

Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

Purification Methods

Cytosine crystallises from H2O as the monohydrate which loses water on heating above 100o. Its solubility in H2O is 0.77%. UV: max 267nm ( 6,100) in H2O pH 8.8 and 275nm ( 10,400) in 0.1N HCl. [Hilbert & Johnson J Am Chem Soc 52 1152 1930, Hilbert et al. J Am Chem Soc 57 552 1935, Beistein 25 III/IV 3654.]

Definition

ChEBI: An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

InChI:InChI=1/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)

71-30-7 Relevant articles

The aminomethylation of adenine, cytosine and guanine

Sloan,Siver

, p. 3997 - 4001 (1984)

-

A facile and effective synthesis of lamivudine 5′-diphosphate

Roy, Béatrice,Lefebvre, Isabelle,Puy, Jean-Yves,Périgaud, Christian

, p. 1250 - 1252 (2011)

We report on the first solution synthesi...

2'-C-cyano-2'-deoxy-1-β-D-arabinofuranosyl-cytosine (CNDAC): A mechanism-based DNA-strand-breaking antitumor nucleoside

Matsuda,Azuma

, p. 461 - 471 (1995)

The antitumor mechanism of action of 2'-...

Nucleosides and Nucleotides. 141. Chemical Stability of a new Antitumor Nucleoside, 2'-C-Cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine in Alkaline Medium: Formation of 2'-C-Cyano-2;-deoxy-1-β-D-ribo-pentofuranosylcytosine and Its Antitumor Activity.

Azuma, Atsushi,Hanaoka, kenji,Kurihara, Atsushi,Kobayashi, Tomowo,Miyauchi, Seiji,et al.

, p. 3391 - 3397 (1995)

We have designed 2'-C-Cyano-2'-deoxy-1-β...

Homochiral crystal generation: Via sequential dehydration and Viedma ripening

Sivakumar, Reajean,Askari, Mohammad S.,Woo, Simon,Madwar, Carolin,Ottenwaelder, Xavier,Bohle, D. Scott,Cuccia, Louis A.

, p. 4277 - 4280 (2016)

1,2-Bis(N-benzoyl-N-methylamino)benzene ...

Evidence for C-1' hydrogen abstraction from modified oligonucleotides by Fe-bleomycin

Duff,De Vroom,Geluk,Hecht,Van Der Marel,Van Boom

, p. 3350 - 3351 (1993)

-

-

Kutscher

, p. 170 (1903)

-

TET-Like Oxidation in 5-Methylcytosine and Derivatives: A Computational and Experimental Study

Jonasson, Niko S. W.,Jan?en, Rachel,Menke, Annika,Zott, Fabian L.,Zipse, Hendrik,Daumann, Lena J.

, p. 3333 - 3340 (2021/09/25)

The epigenetic marker 5-methylcytosine (...

Monitoring the reactivity of formamide on amorphous SiO2 by in-situ UV-Raman spectroscopy and DFT modeling

Balucani, Nadia,Bonino, Francesca,Martra, Gianmario,Pantaleone, Stefano,Signorile, Matteo,Ugliengo, Piero

, (2020/05/28)

Formamide has been recognized in the lit...

Sources of 2,5-diaminoimidazolone lesions in DNA damage initiated by hydroxyl radical attack

Thomas, Caroline Suzanne,Pollard, Hannah Catherine,Razskazovskiy, Yuriy,Roginskaya, Marina

, p. 517 - 524 (2020/09/07)

The present study reports radiation-chem...

Dehalogenation of Halogenated Nucleobases and Nucleosides by Organoselenium Compounds

Mondal, Santanu,Mugesh, Govindasamy

, p. 1773 - 1780 (2019/01/10)

Halogenated nucleosides, such as 5-iodo-...

71-30-7 Process route

N<sup>4</sup>-benzoyl-2',3'-didehydro-2',3'-dideoxycytidine
123413-57-0

N4-benzoyl-2',3'-didehydro-2',3'-dideoxycytidine

4-N-benzoylcytosine
26661-13-2

4-N-benzoylcytosine

Cytosine
71-30-7

Cytosine

Conditions
Conditions Yield
In water; at 40 ℃; Rate constant; degradation in various buffers (acidic condition, < pH 6);
formamide
77287-34-4,77287-35-5,60100-09-6

formamide

pyrimidine-4(3H)-one
51953-18-5,542-27-8

pyrimidine-4(3H)-one

2,4-diaminopyrimidine
156-81-0

2,4-diaminopyrimidine

parabanic acid
120-89-8

parabanic acid

isocytosine
108-53-2,145358-63-0,674-97-5,176772-97-7

isocytosine

Cytosine
71-30-7

Cytosine

oxalic acid
144-62-7,97993-78-7

oxalic acid

guanidine nitrate
113-00-8

guanidine nitrate

2-oxo-propionic acid
127-17-3

2-oxo-propionic acid

uracil
66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6

uracil

2,6-diaminopyrimidin-4-ol
56-06-4

2,6-diaminopyrimidin-4-ol

adenine
66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9

adenine

urea
57-13-6

urea

glycine
56-40-6,18875-39-3,25718-94-9

glycine

Conditions
Conditions Yield
With copper(II) choride dihydrate; In water; at 80 ℃; for 24h; pH=7.57;
1.6 mg
1.7 mg
0.0018 mg
0.1 mg
0.76 mg
0.59 mg
5.6 mg
0.3 mg
0.3 mg
0.13 mg
5 mg
3.8 mg
0.01 mg

71-30-7 Upstream products

  • 7461-50-9
    7461-50-9

    2-chloropyrimidin-4-amine

  • 3289-47-2
    3289-47-2

    4-amino-2-methoxypyrimidine

  • 6220-43-5
    6220-43-5

    4-ethoxypyrimidin-2-one

  • 54308-63-3
    54308-63-3

    2-ethylsulfanyl-pyrimidin-4-ylamine

71-30-7 Downstream products

  • 6220-47-9
    6220-47-9

    4-(Methylamino)-2(1H)-pyrimidinone

  • 14631-20-0
    14631-20-0

    4-N-Acetylcytosine

  • 109102-00-3
    109102-00-3

    3,4,5-trimethoxy-benzoic acid-(2-oxo-1,2-dihydro-pyrimidin-4-ylamide)

  • 26661-13-2
    26661-13-2

    4-N-benzoylcytosine

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