56-92-8

  • Product NameHistamine dihydrochloride
  • Molecular FormulaC5H11Cl2N3
  • Molecular Weight184.068
  • Purity99%
  • Appearancewhite powder
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Product Details

Quick Details

  • CasNo: 56-92-8
  • Molecular Formula: C5H11Cl2N3
  • Appearance: white powder
  • Purity: 99%

Top Quality Chinese Factory supply 56-92-8 Histamine dihydrochloride

  • Molecular Formula:C5H11Cl2N3
  • Molecular Weight:184.068
  • Appearance/Colour:white powder 
  • Melting Point:249-252 °C(lit.) 
  • Boiling Point:331 °C at 760 mmHg 
  • Flash Point:180.3 °C 
  • PSA:54.70000 
  • Density:1.14 g/cm3 
  • LogP:2.21520 

Histamine dihydrochloride(Cas 56-92-8) Usage

Biological Activity

Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo .

Biochem/physiol Actions

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor.

Purification Methods

The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]

General Description

Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

InChI:InChI=1/C5H9N3.ClH/c6-2-1-5-3-7-4-8-5;/h3-4H,1-2,6H2,(H,7,8);1H/p-1

56-92-8 Relevant articles

Preparation method of histamine dihydrochloride

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Paragraph 0028-0048, (2021/07/01)

The invention belongs to the technical f...

Synthesis method of high-purity histamine dihydrochloride

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Paragraph 0032-0046, (2021/01/28)

The invention discloses a synthesis meth...

CONTINUOUS PROCESS FOR THE PREPARATION OF 2-(1H-IMIDAZOL-4-YL) ETHANAMINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

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Page/Page column 6, (2019/01/21)

of the invention The invention relates t...

A histamine dihydrochloride synthetic method

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Paragraph 0027; 0028; 0029, (2017/08/25)

The invention discloses a histamine dihy...

56-92-8 Process route

L-histidine
71-00-1

L-histidine

histamine dichloride
56-92-8

histamine dichloride

Conditions
Conditions Yield
L-histidine; With (R)-Carvone; In propan-1-ol; at 190 ℃; for 0.2h; under 11251.1 Torr; Sealed tube;
With hydrogenchloride; In propan-1-ol; water; at 190 ℃; for 0.0833333h;
92%
Multi-step reaction with 2 steps
1: propan-1-ol / 20 - 190 °C / Green chemistry
2: hydrogenchloride / propan-1-ol / 0.2 h / 190 °C / Green chemistry
With hydrogenchloride; In propan-1-ol;
Multi-step reaction with 3 steps
1: copper(I) bromide / 10 h / 100 - 110 °C / Inert atmosphere; Darkness
2: hydrogenchloride / 30 °C
3: hydrogenchloride / methanol / 30 °C
With hydrogenchloride; copper(I) bromide; In methanol;
N<sup>α</sup>-Trityl-L-histidin
58995-29-2

Nα-Trityl-L-histidin

histamine dichloride
56-92-8

histamine dichloride

Conditions
Conditions Yield
Nα-Trityl-L-histidin; With (R)-Carvone; In propan-1-ol; at 0 - 190 ℃; Green chemistry;
With hydrogenchloride; In propan-1-ol; water; at 190 ℃; for 0.0833333h; Microwave irradiation; Green chemistry;
86%

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