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Lenvatinib is , while it's Molecular Formula is C21H19ClN4O4. Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.
The CAS number of Lenvatinib is 417716-92-8.
More information of Lenvatinib 417716-92-8 are:
Synonyms |
Lenvatinib;6-Quinolinecarboxamide, 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-methoxy-; |
CAS Number |
417716-92-8 |
Molecular Formula |
C21H19ClN4O4 |
Molecular Weight |
426.859 |
Density |
1.469 g/cm3 |
Boiling Point |
627.242 °C at 760 mmHg |
Flash Point |
333.144 °C |
PSA |
115.57000 |
LogP |
5.23610 |
Pka |
13.09±0.70(Predicted) |
Lenvatinib is an inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and VEGFR3 (IC50s = 4 and 5.2 nM, respectively). It also inhibits the related kinases VEGFR1, FGFR1, PDGFRα, PDGFRβ and Kit (IC50s = 22, 46, 51, 39, and 100 nM, respectively). Lenvatinib (30 mg/kg, twice per day) reduces tumor growth in an H146 small cell lung cancer mouse xenograft model and induces tumor regression when administered at a dose of 100 mg/kg twice per day. Formulations containing lenvatinib have been used in the treatment of differentiated thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma.
InChI:InChI=1/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
Articles related to Lenvatinib:
Article |
Source |
Preparation method of lenvatinib and preparation method of lenvatinib intermediate |
- Paragraph 0117; 0122-0123; 0134-0136, (2021/07/01) |
Synthesis method of lenvatinib |
- , (2021/08/28) |
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