78415-72-2

  • Product NameMilrinone
  • Molecular FormulaC12H9N3O
  • Molecular Weight211.223
  • Purity99%
  • AppearanceCrystalline solid
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Product Details

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  • CasNo: 78415-72-2
  • Molecular Formula: C12H9N3O
  • Appearance: Crystalline solid
  • Purity: 99%

High Quality Chinese Factory supply 78415-72-2 Milrinone We supply high quality Milrinone (CAS 78415-72-2), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Milrinone ?

Milrinone is Crystalline solid, while it's Molecular Formula is C12H9N3O. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.

What is the CAS number for Milrinone ?

The CAS number of Milrinone is 78415-72-2.

More information of Milrinone 78415-72-2 are:

Synonyms

6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;Milrinone,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;1,6-Dihydro-2-methyl-6-oxo(3,4-bipyridine)-5-carbonitrile;sodium sulfonate;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile;(3,4-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-;Milrinona [Spanish];WIN 47203-2;Milrinone [USAN:BAN:INN];YM 018;Milrinonum [Latin];Win 47203;[3,4'-Bipyridine]-5-carbonitrile,1,6-dihydro- 2-methyl-6-oxo-;Milrinone (JAN/USAN);Mirinone;

CAS Number

78415-72-2

Molecular Formula

C12H9N3O

Molecular Weight

211.223

Density

1.288 g/cm3

Melting Point

>3000C

Boiling Point

448.685 °C at 760 mmHg

Flash Point

225.157 °C

HS CODE

29337900

PSA

69.54000

LogP

1.61698

Pka

7.21±0.10(Predicted)

What is Milrinone (78415-72-2) used for?

Milrinone is an inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1 μM, respectively. It is selective for PDE3 over PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 263, >300, 17.5, 49.1, and 58.3 μM, respectively). Milrinone (0.1-1 mg/kg) has positive inotropic effects, increasing cardiac contractile force in anesthetized dogs with a concomitant increase in heart rate but not blood pressure. It also increases contractile force in models of propranolol- and verapamil-induced heart failure in anesthetized dogs when administered at an initial dose of 30 μg/kg followed by a continuous 3 μg/kg per minute infusion. Milrinone has vasodilatory effects as well, decreasing mean aortic pressure and increasing venous compliance in anesthetized dogs when administered at an initial dose of 10 μg/kg followed by a continuous 1.7-2.4 μg/kg per minute infusion. Formulations containing milrinone have been used in the treatment of heart failure.

InChI:InChI=1/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

Articles related to Milrinone:

Article

Source

Preparation method of 4-(dimethylamino)-3-(pyridine-4-yl) butyl-3-ene-2-one

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, (2021/10/13)

Preparation process of milrinone

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, (2021/10/13)

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