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Milrinone is Crystalline solid, while it's Molecular Formula is C12H9N3O. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
The CAS number of Milrinone is 78415-72-2.
More information of Milrinone 78415-72-2 are:
Synonyms |
6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;Milrinone,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;1,6-Dihydro-2-methyl-6-oxo(3,4-bipyridine)-5-carbonitrile;sodium sulfonate;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile;(3,4-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-;Milrinona [Spanish];WIN 47203-2;Milrinone [USAN:BAN:INN];YM 018;Milrinonum [Latin];Win 47203;[3,4'-Bipyridine]-5-carbonitrile,1,6-dihydro- 2-methyl-6-oxo-;Milrinone (JAN/USAN);Mirinone; |
CAS Number |
78415-72-2 |
Molecular Formula |
C12H9N3O |
Molecular Weight |
211.223 |
Density |
1.288 g/cm3 |
Melting Point |
>3000C |
Boiling Point |
448.685 °C at 760 mmHg |
Flash Point |
225.157 °C |
HS CODE |
29337900 |
PSA |
69.54000 |
LogP |
1.61698 |
Pka |
7.21±0.10(Predicted) |
Milrinone is an inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1 μM, respectively. It is selective for PDE3 over PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 263, >300, 17.5, 49.1, and 58.3 μM, respectively). Milrinone (0.1-1 mg/kg) has positive inotropic effects, increasing cardiac contractile force in anesthetized dogs with a concomitant increase in heart rate but not blood pressure. It also increases contractile force in models of propranolol- and verapamil-induced heart failure in anesthetized dogs when administered at an initial dose of 30 μg/kg followed by a continuous 3 μg/kg per minute infusion. Milrinone has vasodilatory effects as well, decreasing mean aortic pressure and increasing venous compliance in anesthetized dogs when administered at an initial dose of 10 μg/kg followed by a continuous 1.7-2.4 μg/kg per minute infusion. Formulations containing milrinone have been used in the treatment of heart failure.
InChI:InChI=1/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
Articles related to Milrinone:
Article |
Source |
Preparation method of 4-(dimethylamino)-3-(pyridine-4-yl) butyl-3-ene-2-one |
- , (2021/10/13) |
Preparation process of milrinone |
- , (2021/10/13) |
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