537-73-5

  • Product Name3-Hydroxy-4-methoxycinnamic acid
  • Molecular FormulaC10H10O4
  • Molecular Weight194.187
  • Purity99%
  • AppearanceOff-white crystalline solid
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Product Details

Quick Details

  • CasNo: 537-73-5
  • Molecular Formula: C10H10O4
  • Appearance: Off-white crystalline solid
  • Purity: 99%

High Quality Chinese Manufacturer supply 537-73-5 3-Hydroxy-4-methoxycinnamic acid

  • Molecular Formula:C10H10O4
  • Molecular Weight:194.187
  • Appearance/Colour:Off-white crystalline solid 
  • Vapor Pressure:1.83E-07mmHg at 25°C 
  • Melting Point:230 °C (dec.)(lit.) 
  • Refractive Index:1.5168 (estimate) 
  • Boiling Point:410.2 °C at 760 mmHg 
  • PKA:4.53±0.10(Predicted) 
  • Flash Point:167.6 °C 
  • PSA:66.76000 
  • Density:1.316 g/cm3 
  • LogP:1.49860 

3-Hydroxy-4-methoxycinnamic acid(Cas 537-73-5) Usage

Definition

ChEBI: A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 4 and 3 respectively on the phenyl ring.

General Description

3-Hydroxy-4-methoxycinnamic acid, predominantly trans is available as white crystals. 3-Hydroxy-4-methoxycinnamic acid is isolated from the aerial part of Artemisia capillaris, Chinese medicinal plant. It is a component of chinese herbal medicine used for a pain killer and stomachic. It is an efficient acetylcholine inhibitor. 3-Hydroxy-4-methoxycinnamic acid is bioactive metabolite of Spilanthes acmella Murr. It increases the resistance of low-density lipoprotein (LDL) to oxidation.

InChI:InChI=1/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/p-1/b5-3+

537-73-5 Relevant articles

New long-chained feruloyl ester from the bark of Cedrelinga catenaeformis

El-Seedi

, p. 256 - 258 (2007)

Tetradecyl ferulate and a new n-alkyl es...

Isoferuloyl derivatives of five seed glucosinolates in the crucifer genus Barbarea

Agerbirk, Niels,Olsen, Carl Erik

, p. 610 - 623 (2011)

Five acylated glucosinolates (GSLs) were...

ERYTHRINASINATE, AN ESTER FROM THREE ERYTHRINA SPECIES

Fomum, Z. Tanee,Ayafor, J. Foyere,Wandji, Jean,Fomban, W. Gana,Nkengfack, A. Ephrem

, p. 757 - 759 (1986)

The novel ester n-octacosanyl-3-hydroxy-...

Regioselectivity of Cobalamin-Dependent Methyltransferase Can Be Tuned by Reaction Conditions and Substrate

Pompei, Simona,Grimm, Christopher,Farnberger, Judith E.,Schober, Lukas,Kroutil, Wolfgang

, p. 5977 - 5983 (2020/10/06)

Regioselective reactions represent a sig...

Structural features and antioxidant activities of Chinese quince (Chaenomeles sinensis) fruits lignin during auto-catalyzed ethanol organosolv pretreatment

Cheng, Xi-Chuang,Guo, Xin-Ran,Liu, Hua-Min,Liu, Yu-Lan,Qin, Zhao,Wang, Xue-De

, p. 4348 - 4358 (2020/09/22)

Chinese quince fruits (Chaenomeles sinen...

Bioassay of ferulic acid derivatives as influenza neuraminidase inhibitors

Cui, Man-Ying,Xiao, Meng-Wu,Xu, Lv-Jie,Chen, Yun,Liu, Ai-Lin,Ye, Jiao,Hu, Ai-Xi

, (2019/11/13)

Four series of ferulic acid derivatives ...

Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air

Bao, Xuefei,Chen, Guoliang,Dong, Jinhua,Du, Fangyu,Li, Hui,Liang, Xinjie,Wu, Ying,Zhang, Yongsheng

supporting information, (2020/08/03)

L-(?)-Quebrachitol, a natural product ob...

537-73-5 Process route

isovanillin
621-59-0

isovanillin

malonic acid
141-82-2

malonic acid

trans-3-hydroxy-4-methoxycinnamic acid
537-73-5

trans-3-hydroxy-4-methoxycinnamic acid

Conditions
Conditions Yield
With piperidine; pyridine; for 3h; Heating;
94%
With piperidine; pyridine; In ethanol; for 3h; Heating;
92%
With pyridine; acetic acid; at 130 ℃; for 0.333333h; microwave irradiation;
86%
With N,N-dimethyl acetamide; triethylamine; N,N-dimethyl-formamide; In toluene; for 4h; Reflux;
85%
With piperidine; pyridine; In toluene; at 110 ℃; for 12h; Dean-Stark;
78.4%
With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; for 4h; Reflux; Inert atmosphere;
77.2%
With piperidine; pyridine; at 120 ℃; for 4h;
58%
With piperidine; pyridine; for 3.5h; Heating;
52%
With piperidine; pyridine;
With piperidine; In pyridine;
In pyridine; for 3h; Heating;
With piperidine; pyridine; at 90 ℃;
isovanillin; malonic acid; With piperidine; pyridine; at 120 ℃; for 6h;
With hydrogenchloride; In water; pH=3;
With piperidine; In pyridine; at 120 ℃; for 1.5h;
With pyridine; at 90 ℃;
With pyridine; aniline; In toluene; at 95 ℃;
3-iodo-4-methoxy-<i>trans</i>-cinnamic acid
103261-25-2

3-iodo-4-methoxy-trans-cinnamic acid

trans-3-hydroxy-4-methoxycinnamic acid
537-73-5

trans-3-hydroxy-4-methoxycinnamic acid

Conditions
Conditions Yield
With copper(I) oxide; 1-D-O-Methyl-chiro-inositol; sodium hydroxide; In water; at 120 ℃; for 6h;
81%

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