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Product Details
Definition |
ChEBI: A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 4 and 3 respectively on the phenyl ring. |
General Description |
3-Hydroxy-4-methoxycinnamic acid, predominantly trans is available as white crystals. 3-Hydroxy-4-methoxycinnamic acid is isolated from the aerial part of Artemisia capillaris, Chinese medicinal plant. It is a component of chinese herbal medicine used for a pain killer and stomachic. It is an efficient acetylcholine inhibitor. 3-Hydroxy-4-methoxycinnamic acid is bioactive metabolite of Spilanthes acmella Murr. It increases the resistance of low-density lipoprotein (LDL) to oxidation. |
InChI:InChI=1/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/p-1/b5-3+
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isovanillin
malonic acid
trans-3-hydroxy-4-methoxycinnamic acid
Conditions | Yield |
---|---|
With
piperidine; pyridine;
for 3h;
Heating;
|
94% |
With
piperidine; pyridine;
In
ethanol;
for 3h;
Heating;
|
92% |
With
pyridine; acetic acid;
at 130 ℃;
for 0.333333h;
microwave irradiation;
|
86% |
With
N,N-dimethyl acetamide; triethylamine; N,N-dimethyl-formamide;
In
toluene;
for 4h;
Reflux;
|
85% |
With
piperidine; pyridine;
In
toluene;
at 110 ℃;
for 12h;
Dean-Stark;
|
78.4% |
With
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene;
for 4h;
Reflux;
Inert atmosphere;
|
77.2% |
With
piperidine; pyridine;
at 120 ℃;
for 4h;
|
58% |
With
piperidine; pyridine;
for 3.5h;
Heating;
|
52% |
With
piperidine; pyridine;
|
|
With
piperidine;
In
pyridine;
|
|
In
pyridine;
for 3h;
Heating;
|
|
With
piperidine; pyridine;
at 90 ℃;
|
|
isovanillin; malonic acid;
With
piperidine; pyridine;
at 120 ℃;
for 6h;
With
hydrogenchloride;
In
water;
pH=3;
|
|
With
piperidine;
In
pyridine;
at 120 ℃;
for 1.5h;
|
|
With
pyridine;
at 90 ℃;
|
|
With
pyridine; aniline;
In
toluene;
at 95 ℃;
|
3-iodo-4-methoxy-trans-cinnamic acid
trans-3-hydroxy-4-methoxycinnamic acid
Conditions | Yield |
---|---|
With
copper(I) oxide; 1-D-O-Methyl-chiro-inositol; sodium hydroxide;
In
water;
at 120 ℃;
for 6h;
|
81% |
isovanillin
malonic acid
3-amino-4-methoxy-cinnamic acid
methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate
methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate
dihydroisoferulic acid
(Z)-5-(2'-bromoethenyl)-2-methoxyphenol
3-(3-acetoxy-4-methoxyphenyl)acrylic acid
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