189954-96-9

  • Product NameFirocoxib
  • Molecular FormulaC17H20 O5 S
  • Molecular Weight336.409
  • Purity99%
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Product Details

Quick Details

  • CasNo: 189954-96-9
  • Molecular Formula: C17H20 O5 S
  • Purity: 99%

High Quality Chinese Manufacturer supply 189954-96-9 Firocoxib

  • Molecular Formula:C17H20O5S
  • Molecular Weight:336.409
  • Vapor Pressure:9.72E-13mmHg at 25°C 
  • Melting Point:78-80°C 
  • Refractive Index:1.584 
  • Boiling Point:563.9°Cat760mmHg 
  • Flash Point:294.8°C 
  • PSA:78.05000 
  • Density:1.31 
  • LogP:3.64400 

Firocoxib(Cas 189954-96-9) Usage

Veterinary Drugs and Treatments

Firocoxib is indicated in dogs and horses for the control of pain and inflammation associated with osteoarthritis. A chewable tablet form for dogs and an oral paste for horses are available. Like other NSAIDs, firocoxib can be useful for treating fever, pain, and/or inflammation associated with other conditions, postsurgery, trauma, etc. Firocoxib may also be useful in other species, but information is scant regarding its safety and efficacy. One study in cats (McCann, Rickes et al. 2005) evaluating firocoxib in experimentally induced pyrexia, demonstrated that the drug was effective after a single oral dose in preventing or attenuating pyrexia at all doses studied (0.75 – 3 mg/kg).

Definition

ChEBI: An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoart ritis in horses and dogs.

Brand name

Equioxx (Merial).

InChI:InChI=1/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3

189954-96-9 Relevant articles

Non-luo kaoxi intermediate preparation method (by machine translation)

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Paragraph 0061; 0062; 0063; 0064; 0065; 0066, (2019/06/08)

The invention relates to a preparation m...

Preparation method of firocoxib

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, (2019/10/01)

The invention relates to a preparation m...

Method for preparing firocoxib

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, (2019/11/28)

The invention relates to the technical f...

Preparation method of ferocoxib

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, (2019/11/28)

The invention relates to the technical f...

189954-96-9 Process route

(4-methylsulfanylphenyl)oxoacetic acid ethyl ester
62936-31-6

(4-methylsulfanylphenyl)oxoacetic acid ethyl ester

3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one
189954-96-9

3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: oxone||potassium monopersulfate triple salt / water; Isopropyl acetate / 48 h / 20 °C
2.1: toluene-4-sulfonic acid; ethylene glycol / toluene / 6 h / 110 °C
2.2: 10 h / 5 - 20 °C
2.3: 3 h
3.1: triethylamine / dichloromethane / 4 h / 20 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / Reflux
5.1: tetrabutylammomium bromide; sodium hydroxide / toluene / 48 h / 75 - 80 °C
With oxone||potassium monopersulfate triple salt; tetrabutylammomium bromide; toluene-4-sulfonic acid; ethylene glycol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In dichloromethane; Isopropyl acetate; water; toluene; acetonitrile;
2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester
246869-15-8

2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester

3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one
189954-96-9

3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one

Conditions
Conditions Yield
With isopropyl Trifluoroacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 12h; Reflux;
94%
With isopropyl Trifluoroacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 - 100 ℃; Inert atmosphere;
77%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
With isopropyl Trifluoroacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 95 ℃; for 12h;
4.78 g

189954-96-9 Upstream products

  • 246869-15-8
    246869-15-8

    2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester

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    100-68-5

    methyl-phenyl-thioether

  • 53207-58-2
    53207-58-2

    2-methyl-1-(4-(methylthio)phenyl)-propan-1-one

  • 71867-98-6
    71867-98-6

    2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one

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