499-44-5

  • Product NameHinokitiol
  • Molecular FormulaC10H12O2
  • Molecular Weight164.204
  • Purity99%
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Product Details

Quick Details

  • CasNo: 499-44-5
  • Molecular Formula: C10H12O2
  • Purity: 99%

High Quality Chinese Manufacturer supply 499-44-5 Hinokitiol

  • Molecular Formula:C10H12O2
  • Molecular Weight:164.204
  • Vapor Pressure:8.98E-05mmHg at 25°C 
  • Melting Point:50-52 °C 
  • Refractive Index:1.553 
  • Boiling Point:303.4 °C at 760 mmHg 
  • PKA:7.06±0.30(Predicted) 
  • Flash Point:128.1 °C 
  • PSA:37.30000 
  • Density:1.127 g/cm3 
  • LogP:1.87580 

Hinokitiol(Cas 499-44-5) Usage

benefits

Hinokitiol (β-thujaplicin) is a naturally occurring antioxidant, found in the heartwood of certain plants. It acts as a metal chelator and, also, enhances the activity of superoxide dismutase (Huang et al., 2015). It was found to be very protective in the assay. It has not been previously studied as a HC protectant. In addition to its antioxidant properties, hinokitiol has been shown to reduce inflammation via suppression of NFκB, and metalloproteinases, and to activate caspase 3. The former activities could contribute to its protective effect.Hinokitiol is a superpower ingredient that has anti-inflammatory, antioxidant, antibacterial, anti-fungal and anti-melanogenic properties. Best of all, hinokitiol is as gentle as it is powerful. Hinokitiol’s properties allow it to target the inflammatory redness and blemishes seen in rosacea and acne. Hinokitiol is effective against P. acnes bacteria, and there is no known acquired resistance to it, unlike other prescription antibiotics.

Safety

The safety of hinokitiol has been tested in rats and no carcinogenic effect to rats was found.In 2006, hinokitiol was categorized under the Domestic substances list (DSL) in Canada as non-persistent, non-bioaccumulative and non-toxic to aquatic organisms.

Anticancer Research

Studied in xenograft tumors such lung adenocarcinoma cell, EGFR-TKI-resistantlines PC9-IR and H1975 in which the growth inhibition was observed, a novel antitumormechanism was hypothesized. In summary, the hinokitiol can induce DNAdamage and autophagy (Rodrigues et al. 2015).

Definition

ChEBI: A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.

InChI:InChI=1/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12)

499-44-5 Relevant articles

Method for preparing hinokitiol

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Paragraph 0083-0086, (2019/01/23)

The invention discloses a method for pre...

A high-purity chinese juniper methyl alcohol of preparation method (by machine translation)

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Paragraph 0057; 0058; 0059; 0061; 0063; 0065; 0067, (2018/08/03)

The invention discloses a method for pre...

Method for preparing high-purity hinokitiol and coordination complex thereof

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Paragraph 0060; 0061, (2018/10/19)

The invention belongs to the technical f...

Preparation method of beta-thujaplicine

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Paragraph 0028; 0029; 0030; 0031; 0032; 0035; 0036, (2018/11/03)

The invention belongs to the technical f...

499-44-5 Process route

4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one
698-47-5

4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one

isopropenyltrimethylstannane
3043-46-7

isopropenyltrimethylstannane

hinokitiol
499-44-5

hinokitiol

Conditions
Conditions Yield
4-bromo-2-hydroxycycklohepta-2,4,6-trien-1-one; isopropenyltrimethylstannane; With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; for 1h; Reflux;
With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 24h; under 760.051 Torr;
53%
isopropoxyboronic acid
52732-22-6

isopropoxyboronic acid

2-hydroxy-4-chloro-2,4,6-cycloheptatrien-1-one
698-48-6

2-hydroxy-4-chloro-2,4,6-cycloheptatrien-1-one

hinokitiol
499-44-5

hinokitiol

Conditions
Conditions Yield
With potassium phosphate; In tetrahydrofuran; at 100 ℃; for 2h;
97.5%

499-44-5 Upstream products

  • 35193-01-2
    35193-01-2

    β-isopropyltropolone

  • 55076-44-3
    55076-44-3

    1-isopropyl-8-oxa-bicyclo[3.2.1]oct-6-en-3-one

  • 10599-59-4
    10599-59-4

    2-isopropylfuran

  • 55076-46-5
    55076-46-5

    3-Isopropylcyclohepta-2,6-dienon

499-44-5 Downstream products

  • 55076-49-8
    55076-49-8

    2-amino-6-isopropyl-cycloheptatrienone

  • 103028-78-0
    103028-78-0

    2-amino-4-isopropyl-cycloheptatrienone

  • 108973-66-6
    108973-66-6

    2-benzylamino-6-isopropyl-cycloheptatrienone

  • 108975-97-9
    108975-97-9

    2-benzylamino-4-isopropyl-cycloheptatrienone

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