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1401708-83-5

  • Product NameDihexa
  • Molecular FormulaC27H44N4O5
  • Molecular Weight504.67
  • Purity99%
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  • CasNo： 1401708-83-5
  • Molecular Formula： C27H44N4O5
  • Purity： 99%

Quality products make an important contribution to long-term revenue and profitability. High Quality Chinese Manufacturer supply 1401708-83-5 Dihexa

1.What is the Dihexa ?

Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease.

N-hexanoic-L-tyrosine-L-isoleucine-<sup>(6)</sup>-aminohexanoic amide
1401708-83-5

N-hexanoic-L-tyrosine-L-isoleucine-(6)-aminohexanoic amide

C<sub>27</sub>H<sub>45</sub>N<sub>4</sub>O<sub>8</sub>P*2H<sub>3</sub>N

C27H45N4O8P*2H3N

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 2 h
2.2: pH 8
With lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; In acetic acid; N,N-dimethyl-formamide;
 

2.What is the CAS number for Dihexa ?

The CAS number of Dihexa is 1401708-83-5.

More information of Dihexa 1401708-83-5 are:

CAS Number

 1401708-83-5

Density

 1.111±0.06 g/cm3(Predicted)

Boiling Point

 866.2±65.0 °C(Predicted)

PSA

 150.62000

LogP

 4.56560

Pka

 9.83±0.15(Predicted)

3.What are another words for Dihexa ?

Synonyms for Dihexa 1401708-83-5:Dihexa

4.What is the molecular formula of Dihexa?

The chemical formula of  Dihexa is C27H44N4O5 which containing 27 Carbon atoms,44 Hydrogen atoms,4 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of  Dihexa is 504.67.

5.What is Dihexa (1401708-83-5) used for?

Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.

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